Diagnosis of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma on pleural fluid cytology

Nancy Y Greenland; Chuanyi M Lu; Stephen Cook; Yue Peng

doi:10.1002/dc.24855

Diagnosis of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma on pleural fluid cytology

Diagn Cytopathol. 2021 Dec;49(12):E458-E461. doi: 10.1002/dc.24855. Epub 2021 Aug 18.

Authors

Nancy Y Greenland^{1

2}, Chuanyi M Lu^{1

2}, Stephen Cook^{1

2}, Yue Peng^{1

2}

Affiliations

¹ Pathology and Laboratory Medicine Services, San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.
² Department of Pathology and Laboratory Medicine, University of California, San Francisco, California, USA.

PMID: 34406711
DOI: 10.1002/dc.24855

Abstract

ALK-negative anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin T-cell lymphoma. Compared to ALK-positive ALCL, patients with ALK-negative ALCL typically are older, present with nodal disease, and have lower survival rates. We report a unique presentation of ALK-negative ALCL in a pleural fluid. Cell block preparation enabled both confirmation of the diagnosis via immunohistochemical staining and gene rearrangement testing for prognostic information.

Keywords: anaplastic large cell lymphoma; anaplastic lymphoma kinase; pleural fluid cytology.

Publication types

Clinical Trial

MeSH terms

Aged
Anaplastic Lymphoma Kinase / metabolism*
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymphoma, Large-Cell, Anaplastic / diagnosis*
Lymphoma, Large-Cell, Anaplastic / enzymology*
Male
Pleura / enzymology*

Substances

Anaplastic Lymphoma Kinase