Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide

MeSH terms

• Antineoplastic Agents, Alkylating / pharmacology
• Antineoplastic Agents, Alkylating / therapeutic use
• Brain Neoplasms / drug therapy
• Brain Neoplasms / genetics
• Brain Neoplasms / pathology
• Cell Line, Tumor
• DNA Modification Methylases / genetics
• DNA Modification Methylases / metabolism
• DNA Repair Enzymes / genetics
• DNA Repair Enzymes / metabolism
• Dacarbazine / analogs & derivatives
• Dacarbazine / pharmacology
• Dacarbazine / therapeutic use
• Enhancer Elements, Genetic* / genetics
• Gene Expression Regulation, Neoplastic / drug effects
• Gene Regulatory Networks* / drug effects
• Glioma* / drug therapy
• Glioma* / genetics
• Glioma* / pathology
• Humans
• Temozolomide* / pharmacology
• Temozolomide* / therapeutic use
• Tumor Suppressor Proteins / genetics
• Tumor Suppressor Proteins / metabolism