Sustained remission after ruxolitinib and chimeric antigen receptor T-cell therapy bridged to a second allogeneic hematopoietic stem cell transplantation for relapsed Philadelphia chromosome-like B-cell precursor acute lymphoblastic leukemia with novel NPHP3-JAK2 fusion

Genes Chromosomes Cancer. 2022 Jan;61(1):55-58. doi: 10.1002/gcc.22995. Epub 2021 Sep 1.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Combined Modality Therapy
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immunotherapy, Adoptive*
  • Janus Kinase 2 / antagonists & inhibitors
  • Janus Kinase 2 / genetics*
  • Kinesins / genetics*
  • Male
  • Nitriles / therapeutic use*
  • Oncogene Proteins, Fusion / antagonists & inhibitors
  • Oncogene Proteins, Fusion / genetics*
  • Philadelphia Chromosome
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / therapy*
  • Pyrazoles / therapeutic use*
  • Pyrimidines / therapeutic use*
  • Receptors, Chimeric Antigen / therapeutic use*
  • Remission Induction
  • Transplantation, Homologous
  • Young Adult

Substances

  • Nitriles
  • Oncogene Proteins, Fusion
  • Pyrazoles
  • Pyrimidines
  • Receptors, Chimeric Antigen
  • ruxolitinib
  • JAK2 protein, human
  • Janus Kinase 2
  • nephrocystin-3, human
  • Kinesins