Initial Experiences with the MitraClip G4: Review of the Novel Device Features

Innovations (Phila). 2021 Sep-Oct;16(5):448-455. doi: 10.1177/15569845211030862. Epub 2021 Aug 23.

Abstract

Objective: Percutaneous edge-to-edge mitral valve repair is an evolving procedure with increasing indications for use. The MitraClip™ G4 is the newest device with 4 device options, each with distinct characteristics. While the NTR and XTR clips have been in use, the G4 adds 2 new wider clips with additional features, the NTW and XTW.

Methods: We reviewed 26 cases employing the MitraClip G4 at our institution from November 2019 to March 2020.

Results: The NTR, XTR, NTW, and XTW clips were used in 3 (11.5%), 0 (0.0%), 16 (61.5%), and 11 (42.3%) cases, respectively. Median mitral regurgitation grade was reduced from 4+ to 1+, though 7 (27%) cases had 2+ residual mitral regurgitation.

Conclusions: The new G4 device includes simplified instructions for use, the option of a wider clip, controlled gripper actuation, and potential left atrial pressure monitoring. The newest MitraClip G4 device allows for potential improved treatment options for patients with mitral regurgitation.

Keywords: MitraClip; controlled gripper actuation; mitral regurgitation; percutaneous edge-to-edge mitral valve repair.

MeSH terms

  • Cardiac Catheterization
  • Cardiac Surgical Procedures*
  • Heart Valve Prosthesis Implantation*
  • Humans
  • Mitral Valve / diagnostic imaging
  • Mitral Valve / surgery
  • Mitral Valve Insufficiency* / surgery
  • Treatment Outcome