Enantiomerically Enriched α-Borylzinc Reagents by Nickel-Catalyzed Carbozincation of Vinylboronic Esters

J Am Chem Soc. 2021 Sep 8;143(35):14189-14195. doi: 10.1021/jacs.1c05274. Epub 2021 Aug 23.

Abstract

In this paper is described a synthesis of enantiomerically enriched, configurationally stable organozinc reagents by catalytic enantioselective carbozincation of a vinylboronic ester. This process furnishes enantiomerically enriched α-borylzinc intermediates that are shown to undergo stereospecific reactions, producing enantioenriched secondary boronic ester products. The properties of the intermediate α-borylzinc reagent are probed and the synthetic utility of the products is demonstrated by application to the synthesis of (-)-aphanorphine and (-)-enterolactone.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alcohols / chemical synthesis
  • Boron Compounds / chemical synthesis*
  • Boronic Acids / chemistry*
  • Catalysis
  • Models, Chemical
  • Nickel / chemistry
  • Organometallic Compounds / chemical synthesis*
  • Stereoisomerism
  • Vinyl Compounds / chemistry*
  • Zinc / chemistry

Substances

  • Alcohols
  • Boron Compounds
  • Boronic Acids
  • Organometallic Compounds
  • Vinyl Compounds
  • Nickel
  • Zinc