Radiological-pathological signatures of patients with COVID-19-related pneumomediastinum: is there a role for the Sonic hedgehog and Wnt5a pathways?

Elisa Baratella; Rossana Bussani; Fabrizio Zanconati; Cristina Marrocchio; Giudici Fabiola; Luca Braga; Serena Maiocchi; Giorgio Berlot; Maria Concetta Volpe; Edoardo Moro; Paola Confalonieri; Maria Assunta Cova; Marco Confalonieri; Francesco Salton; Barbara Ruaro

doi:10.1183/23120541.00346-2021

Radiological-pathological signatures of patients with COVID-19-related pneumomediastinum: is there a role for the Sonic hedgehog and Wnt5a pathways?

ERJ Open Res. 2021 Aug 23;7(3):00346-2021. doi: 10.1183/23120541.00346-2021. eCollection 2021 Jul.

Authors

Elisa Baratella¹, Rossana Bussani², Fabrizio Zanconati², Cristina Marrocchio¹, Giudici Fabiola^{3

4}, Luca Braga⁵, Serena Maiocchi⁵, Giorgio Berlot⁶, Maria Concetta Volpe⁵, Edoardo Moro⁶, Paola Confalonieri⁷, Maria Assunta Cova¹, Marco Confalonieri⁷, Francesco Salton⁷, Barbara Ruaro⁷

Affiliations

¹ Dept of Radiology, Cattinara Hospital, University of Trieste, Trieste, Italy.
² Dept of Pathology, Cattinara University Hospital, Trieste, Italy.
³ Biostatistics Unit, Dept of Medicine, Surgery and Health Sciences, Cattinara Hospital, University of Trieste, Trieste, Italy.
⁴ Unit of Biostatistics, Epidemiology and Public Health, Dept of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
⁵ Functional Cell Biology Unit, ICGEB, Trieste, Italy.
⁶ Intensive Care Unit, Cattinara University Hospital, Trieste, Italy.
⁷ Pulmonology Dept, Cattinara University Hospital, Trieste, Italy.

Abstract

Pneumomediastinum is a rare complication of ARDS but is more common during #COVID19. The fibrous hyaline degeneration of the tracheal rings seen in this autoptic series is an original observation that has not been previously described in COVID-19 patients. https://bit.ly/3vxTQde.