Cutaneous eccrine inflammation and necrosis: review of inflammatory disorders affecting the eccrine apparatus including new associations

Hadir Shakshouk; Emma F Johnson; Margot S Peters; Carilyn N Wieland; Nneka I Comfere; Julia S Lehman

doi:10.1016/j.humpath.2021.08.005

Cutaneous eccrine inflammation and necrosis: review of inflammatory disorders affecting the eccrine apparatus including new associations

Hum Pathol. 2021 Dec:118:71-85. doi: 10.1016/j.humpath.2021.08.005. Epub 2021 Aug 24.

Authors

Hadir Shakshouk¹, Emma F Johnson², Margot S Peters², Carilyn N Wieland², Nneka I Comfere², Julia S Lehman³

Affiliations

¹ Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Dermatology, Andrology and Venereology, Alexandria University, Alexandria, 21131, Egypt.
² Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
³ Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address: [email protected].

PMID: 34450084
DOI: 10.1016/j.humpath.2021.08.005

Abstract

Despite being frequently overlooked during the examination of histopathological sections, eccrine sweat glands can offer clues for diagnosing various skin conditions. They provide important functions and can lead to several diseases when inflamed or injured. This review article provides information regarding eccrine physiology as well as well-established and novel entities that occur in association with eccrine gland pathology.

Keywords: Dermatopathology; Eccrine glands; Histopathology; Inflammation; Metaplasia; Necrosis; Skin.

Publication types

Review

MeSH terms

Eccrine Glands / pathology*
Humans
Inflammation / pathology
Necrosis / pathology