Acute cardiopulmonary failure in a young woman with high-risk gestational trophoblastic neoplasia: A case of induction chemotherapy during extracorporeal membrane oxygenation

Lindsey A McAlarnen; Nathan J Smith; Beth A Nance; M Tracy Zundel; Erin A Bishop

doi:10.1016/j.gore.2021.100849

Acute cardiopulmonary failure in a young woman with high-risk gestational trophoblastic neoplasia: A case of induction chemotherapy during extracorporeal membrane oxygenation

Gynecol Oncol Rep. 2021 Aug 14:37:100849. doi: 10.1016/j.gore.2021.100849. eCollection 2021 Aug.

Authors

Lindsey A McAlarnen¹, Nathan J Smith², Beth A Nance², M Tracy Zundel³, Erin A Bishop¹

Affiliations

¹ Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.
² Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
³ Department of Anesthesiology, Division of Critical Care Anesthesia, Medical College of Wisconsin, Milwaukee, WI, United States.

Abstract

•Early use of extracorporeal membrane oxygenation (ECMO) is valuable when pulmonary tumor burden from GTN is high.•Induction chemotherapy of cisplatin and etoposide was administered during ECMO successfully.•The induction chemotherapy regimen led to exponential decline in beta-HCG after 1 cycle.•Collaboration of subspecialists is necessary to treat coexisting malignancy and cardiopulmonary failure associated with GTN.

Keywords: Cardiopulmonary failure; Extracorporeal membrane oxygenation (ECMO); Gestational trophoblastic neoplasia; High-risk GTN; Induction chemotherapy; Respiratory failure.

Publication types

Case Reports