Trust your gut: an early life lesson for T cells

Trends Immunol. 2021 Oct;42(10):844-845. doi: 10.1016/j.it.2021.08.010. Epub 2021 Sep 1.

Abstract

Zegarra-Ruiz et al. demonstrate that gut microbe-specific T cells are selected within the thymus exclusively during early life in mice. This selection is dependent on CX3CR1+ dendritic cells migrating from the gut carrying bacterially derived antigens into the thymus. This offers new insight into how gut microbiota influence T cell development.

Publication types

  • Research Support, N.I.H., Intramural
  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Gastrointestinal Microbiome*
  • Mice
  • T-Lymphocytes*