The genomics of heart failure: design and rationale of the HERMES consortium

Affiliations

• ¹ Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
• ² Health Data Research UK London, University College London, London, UK.
• ³ BHF Research Accelerator, University College London, London, UK.
• ⁴ Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
• ⁵ Institute of Cardiovascular Science, University College London, London, UK.
• ⁶ Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• ⁷ National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
• ⁸ Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
• ⁹ Department of Medicine, Imperial College London, London, UK.
• ¹⁰ Pfizer Worldwide Research & Development, Cambridge, MA, USA.
• ¹¹ Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
• ¹² Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.
• ¹³ Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• ¹⁴ Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
• ¹⁵ Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.
• ¹⁶ National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
• ¹⁷ Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
• ¹⁸ School of Health and Social Sciences, Dalarna University, Falun, Sweden.
• ¹⁹ Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
• ²⁰ Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
• ²¹ The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.
• ²² UCL Genetics Institute, University College London, London, UK.
• ²³ Department of Clinical Sciences, Lund University, Malmö, Sweden.
• ²⁴ Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ²⁵ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
• ²⁶ Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
• ²⁷ Montreal Heart Institute, Montreal, Quebec, Canada.
• ²⁸ Regeneron Genetics Center, Tarrytown, NY, USA.
• ²⁹ Department of Biostatistics, University of Washington, Seattle, WA, USA.
• ³⁰ Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
• ³¹ Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.
• ³² Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ³³ Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ³⁴ Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
• ³⁵ Maastricht University Medical Center, Maastricht, The Netherlands.
• ³⁶ Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
• ³⁷ Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ³⁸ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• ³⁹ Harvard Medical School, Boston, MA, USA.
• ⁴⁰ Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
• ⁴¹ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
• ⁴² Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
• ⁴³ Robertson Centre for Biostatistics & Glasgow Clinical Trials Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.
• ⁴⁴ National Heart and Lung Institute, Imperial College, London, UK.
• ⁴⁵ Department of Biostatistics, University of Liverpool, Liverpool, UK.
• ⁴⁶ Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.
• ⁴⁷ Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.
• ⁴⁸ MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, UK.
• ⁴⁹ Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany.
• ⁵⁰ The Alan Turing Institute, British Library, London, UK.
• ⁵¹ Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
• ⁵² Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
• ⁵³ DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
• ⁵⁴ Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
• ⁵⁵ Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
• ⁵⁶ Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, Suresnes, France.
• ⁵⁷ Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
• ⁵⁸ Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
• ⁵⁹ Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
• ⁶⁰ Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.
• ⁶¹ deCODE genetics/Amgen Inc., Reykjavik, Iceland.
• ⁶² School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
• ⁶³ Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
• ⁶⁴ Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
• ⁶⁵ Department of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
• ⁶⁶ Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• ⁶⁷ Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
• ⁶⁸ Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
• ⁶⁹ Netherlands Heart Institute, Utrecht, The Netherlands.
• ⁷⁰ TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• ⁷¹ Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
• ⁷² Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
• ⁷³ Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
• ⁷⁴ Duke Molecular Physiology Institute, Durham, NC, USA.
• ⁷⁵ Division of Psychiatry, University College of London, London, UK.
• ⁷⁶ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
• ⁷⁷ Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
• ⁷⁸ Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
• ⁷⁹ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
• ⁸⁰ Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA.
• ⁸¹ Genentech Inc., San Francisco, CA, USA.
• ⁸² Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
• ⁸³ Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
• ⁸⁴ Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
• ⁸⁵ BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
• ⁸⁶ Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden.
• ⁸⁷ Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
• ⁸⁸ Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
• ⁸⁹ Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria.
• ⁹⁰ Finnish Institute for Health and Welfare, Helsinki, Finland.
• ⁹¹ Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
• ⁹² Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
• ⁹³ National Institute for Health and Welfare, Helsinki, Finland.
• ⁹⁴ Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
• ⁹⁵ Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.
• ⁹⁶ The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
• ⁹⁷ Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
• ⁹⁸ Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA.
• ⁹⁹ Department of Epidemiology, University of Washington, Seattle, WA, USA.
• ¹⁰⁰ Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA.
• ¹⁰¹ Faculty of Medicine, Department of Medicine, University of Iceland, Reykjavik, Iceland.
• ¹⁰² Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, Denmark.
• ¹⁰³ Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
• ¹⁰⁴ Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
• ¹⁰⁵ Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.
• ¹⁰⁶ Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.
• ¹⁰⁷ Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
• ¹⁰⁸ Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
• ¹⁰⁹ Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ¹¹⁰ Department of Clinical Medicine, University of Turku, Turku, Finland.
• ¹¹¹ Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
• ¹¹² Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA.
• ¹¹³ Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand.
• ¹¹⁴ Department of Medicine, University of Washington, Seattle, WA, USA.
• ¹¹⁵ Human Genetics, GlaxoSmithKline, Collegeville, PA, USA.
• ¹¹⁶ CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, Université de Lorraine, Nancy, France.
• ¹¹⁷ Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
• ¹¹⁸ Heart and Vascular Institute, Henry Ford Hospital, Detroit, MI, USA.
• ¹¹⁹ Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
• ¹²⁰ Duke Clinical Research Institute, Durham, NC, USA.
• ¹²¹ Regeneron Pharmaceuticals, Cardiovascular Research, Tarrytown, NY, USA.
• ¹²² Division of Cardiovascular Medicine and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University, Nashville, TN, USA.
• ¹²³ Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA.
• ¹²⁴ Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden.
• ¹²⁵ The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.