Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains

Cytotherapy. 2022 Jan;24(1):10-15. doi: 10.1016/j.jcyt.2021.07.006. Epub 2021 Sep 2.

Abstract

Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.

Keywords: COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • COVID-19 Vaccines
  • COVID-19*
  • Humans
  • SARS-CoV-2*
  • Spike Glycoprotein, Coronavirus / genetics
  • T-Lymphocytes
  • Vaccination

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • COVID-19 Vaccines
  • Spike Glycoprotein, Coronavirus

Supplementary concepts

  • SARS-CoV-2 variants