High-Sensitivity Cardiac Troponin T Is a Risk Factor for Major Adverse Cardiovascular Events and All-Cause Mortality: A 9.5-Year Follow-Up Study

Xiaona Wang; Peiqi Wang; Ruihua Cao; Xu Yang; Wenkai Xiao; Yun Zhang; Li Sheng; Ping Ye

doi:10.1155/2021/6647987

High-Sensitivity Cardiac Troponin T Is a Risk Factor for Major Adverse Cardiovascular Events and All-Cause Mortality: A 9.5-Year Follow-Up Study

Cardiol Res Pract. 2021 Aug 25:2021:6647987. doi: 10.1155/2021/6647987. eCollection 2021.

Authors

Xiaona Wang¹, Peiqi Wang², Ruihua Cao¹, Xu Yang¹, Wenkai Xiao¹, Yun Zhang¹, Li Sheng¹, Ping Ye¹

Affiliations

¹ Department of Geriatric Cardiology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
² Department of Anesthesiology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Abstract

Background: The relationship between high-sensitivity cardiac troponin T (hs-cTnT) and different cardiovascular events has been observed in several large community studies, and the results have been controversial. However, there is currently no cross-sectional or longitudinal follow-up study on hs-cTnT in the Chinese population.

Methods: We analyzed the association of plasma hs-cTnT levels with major adverse cardiovascular events (MACEs) and all-cause mortality in 1325 subjects from a longitudinal follow-up community-based population in Beijing, China.

Results: In the Cox proportional hazards models analysis, the risk of MACEs increased with the increase of hs-cTnT levels (HR, 1.223, 95% CI, 1.054-1.418, P=0.008). Increased hs-cTnT levels were associated with coronary events (HR, 1.391, 95% CI, 1.106-1.749, P=0.005) in Model 4. Cox proportional risk regression model analysis revealed that increased hs-cTnT levels were associated with an increased risk of mortality (HR, 1.763, 95% CI, 1.224-2.540, P=0.002), even after adjusting hs-CRP and NT-proBNP. The area under the ROC curve for predicting MACEs was 0.559 (95% CI, 0.523-0.595, P=0.001). The areas under the ROC curve for predicting coronary events and mortality were 0.629 (95% CI, 0.580-0.678, P < 0.001) and 0.644 (95% CI, 0.564-0.725, P < 0.001), respectively.

Conclusions: Our findings in the Chinese cohort support that hs-cTnT is a risk factor for major adverse cardiovascular events and all-cause mortality.