Percutaneous Intracoronary Delivery of Plasma Extracellular Vesicles Protects the Myocardium Against Ischemia-Reperfusion Injury in Canis

Hypertension. 2021 Nov;78(5):1541-1554. doi: 10.1161/HYPERTENSIONAHA.121.17574. Epub 2021 Sep 7.

Hongyun Wang^#^{1

2}, Rusitanmujiang Maimaitiaili^#³, Jianhua Yao^#³, Yuling Xie¹, Sujing Qiang³, Fan Hu⁴, Xiang Li³, Chao Shi¹, Peng Jia³, Haotian Yang³, Meng Wei¹, Juan Zhao¹, Zheng Zhou³, Jinxin Xie¹, Jizong Jiang², Haidong Cai⁴, Joost P G Sluijter^{5

6}, Yawei Xu³, Yi Zhang³, Junjie Xiao^{1

2}

¹ Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University, The Sixth People's Hospital of Nantong (H.W., Y.X., C.S., M.W., J.Z., J.X., J.X.), Shanghai University, China.
² Shanghai Engineering Research Center of Organ Repair, School of Life Science (H.W., J.J., J.X.), Shanghai University, China.
³ Department of Cardiology (R.M., J.Y., S.Q., X.L., P.J., H.Y., Z.Z., Y.X., Y.Z.), Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
⁴ Department of Nuclear Medicine (F.H., H.C.), Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
⁵ Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, the Netherlands (J.P.G.S.).
⁶ UMC Utrecht Regenerative Medicine Center, University Medical Center, Utrecht University, the Netherlands (J.P.G.S.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: extracellular vesicles; infarction; microRNA; plasma; reperfusion injury.