In vivo measurement of the attenuation coefficient of the sclera and ciliary muscle

Gabrielle Monterano Mesquita; Disha Patel; Yu-Cherng Chang; Florence Cabot; Marco Ruggeri; Sonia H Yoo; Arthur Ho; Jean-Marie A Parel; Fabrice Manns

doi:10.1364/BOE.427286

In vivo measurement of the attenuation coefficient of the sclera and ciliary muscle

Biomed Opt Express. 2021 Jul 20;12(8):5089-5106. doi: 10.1364/BOE.427286. eCollection 2021 Aug 1.

Authors

Gabrielle Monterano Mesquita^{1

2}, Disha Patel^{1

2}, Yu-Cherng Chang^{1

2}, Florence Cabot¹, Marco Ruggeri^{1

2}, Sonia H Yoo^{1

2}, Arthur Ho^{1

2

3

4}, Jean-Marie A Parel^{1

2

3}, Fabrice Manns^{1

2}

Affiliations

¹ Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
² Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL 33146, USA.
³ Brien Holden Vision Institute, Sydney, NSW 2052, Australia.
⁴ School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2033, Australia.

Abstract

We acquired 1325 nm OCT images of the sclera and ciliary muscle of human subjects. The attenuation coefficients of the sclera and ciliary muscle were determined from a curve fit of the average intensity profile of about 100 A-lines in a region of interest after correction for the effect of beam geometry, using a single scattering model. The average scleral attenuation coefficient was 4.13 ± 1.42 mm^-1 with an age-related decrease that was near the threshold for statistical significance (p = 0.053). The average ciliary muscle attenuation coefficient was 1.72 ± 0.88 mm^-1, but this value may be an underestimation due to contributions from multiple scattering. Overall, the results suggest that inter-individual variations in scleral attenuation contribute to variability in the quality of transscleral OCT images of the ciliary muscle and the outcome of transscleral laser therapies.

Abstract

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