A polarized anchor for hematopoietic stem cells: Synapse between stem cells and their niche?

J Cell Biol. 2021 Oct 4;220(10):e202108031. doi: 10.1083/jcb.202108031. Epub 2021 Sep 13.

Abstract

Multipotent hematopoietic stem cells are maintained by the bone marrow niche, but how niche-derived membrane-bound stem cell factor (mSCF) regulates HSCs remains unclear. In this issue, Hao et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202010118) describe that mSCF, synergistically with VCAM-1, induces large, polarized protrusions that serve as anchors for HSCs to their niche.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bone Marrow Cells
  • Hematopoietic Stem Cells*
  • Stem Cell Niche*
  • Synapses