Short-term effect of fine particulate matter and ozone on non-accidental mortality and respiratory mortality in Lishui district, China

Background: In recent years, air pollution has become an imminent problem in China. Few studies have investigated the impact of air pollution on the mortality of the middle-aged and elderly people. Therefore, this study aims to evaluate the impact of PM_2.5 (fine particulate matter) and O₃ (ozone) on non-accidental mortality and respiratory mortality of the middle-aged and elderly people in Lishui District of Nanjing and provide the evidence for potential prevention and control measures of air pollution.

Method: Using daily mortality and atmospheric monitoring data from 2015 to 2019, we applied a generalized additive model with time-series analysis to evaluate the association of PM_2.5 and O₃ exposure with daily non-accidental mortality and respiratory mortality in Lishui District. Using the population attributable fractions to estimate the death burden caused by short-term exposure to O₃ and PM_2.5。.

Result: For every 10 μg/m³ increase in PM_2.5, non-accidental mortality increased 0.94% with 95% confidence interval (CI) between 0.05 and 1.83%, and PM_2.5 had a more profound impact on females than males. For every 10 μg/m³ increase in O₃, respiratory mortality increased 1.35% (95% CI: 0.05, 2.66%) and O₃ had a more profound impact on males than females. Compared with the single pollutant model, impact of the two-pollutant model on non-accidental mortality and respiratory mortality slightly decreased. In summer and winter as opposed to the other seasons, O₃ had a more obvious impact on non-accidental mortality. The population attributable fractions of non-accidental mortality were 0.84% (95% CI:0.00, 1.63%) for PM_2.5 and respiratory mortality were 0.14% (95% CI:0.01, 0.26%) for O₃. For every 10 μg/m³ decrease in PM_2.5, 122 (95% CI: 6, 237) non-accidental deaths could be avoided. For every 10 μg/m³ decrease in O₃, 10 (95% CI: 1, 38) respiratory deaths could be avoided.

Conclusion: PM_2.5 and O₃ could significantly increase the risk of non-accidental and respiratory mortality in the middle-aged and elderly people in Lishui District of Nanjing. Exposed to air pollutants, men were more susceptible to O₃ damage, and women were more susceptible to PM_2.5 damage. Reduction of PM_2.5 and O₃ concentration in the air may have the potential to avoid considerable loss of lives.