Two New Oleanane-Triterpenoid Saponins from Clinopodium gracile

Chem Biodivers. 2021 Nov;18(11):e2100672. doi: 10.1002/cbdv.202100672. Epub 2021 Oct 20.

Abstract

Two new oleanane-triterpenoid saponins, clinograsaponins A (1) and B (2), together with twelve known ones (3-14), were isolated from the whole herb of Clinopodium gracile (Bentham) Matsumura. Their structures were determined by spectroscopic analysis and chemical method. All the isolated compounds were evaluated for their activities against ATP-citrate lyase (ACLY) and nuclear factor kappa B (NF-κB).

Keywords: Clinopodium gracile; Lamiaceae; oleanane; triterpenoid saponins.

MeSH terms

  • ATP Citrate (pro-S)-Lyase / antagonists & inhibitors*
  • ATP Citrate (pro-S)-Lyase / metabolism
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Lamiaceae / chemistry*
  • Molecular Conformation
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Stereoisomerism

Substances

  • Enzyme Inhibitors
  • NF-kappa B
  • Plant Extracts
  • ATP Citrate (pro-S)-Lyase