The Heart of the Problem in Multisystem Inflammatory Syndrome in Children

Brittany P Boribong; Puneeta Arya; Lael M Yonker

doi:10.1016/j.medj.2021.08.008

The Heart of the Problem in Multisystem Inflammatory Syndrome in Children

Med. 2021 Sep 10;2(9):993-995. doi: 10.1016/j.medj.2021.08.008.

Authors

Brittany P Boribong^{1

2}, Puneeta Arya^{3

2}, Lael M Yonker^{1

4

2}

Affiliations

¹ Massachusetts General Hospital, Mucosal Immunology and Biology Research Center, Boston, MA, USA.
² Harvard Medical School, Boston, MA, USA.
³ Massachusetts General Hospital, Department of Pediatrics, Cardiology Division, Boston, MA, USA.
⁴ Massachusetts General Hospital, Department of Pediatrics, Pulmonary Division, Boston, MA, USA.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a severe, life-threatening, post-COVID-19 hyperinflammatory illness that is not yet fully understood. In this issue of Med, de Cevins et al. used a multi-parametric approach to define COVID-19-related disease, specifically identifying a molecular signature of the most severe form of COVID-19-related illness: MIS-C with myocarditis.¹.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

COVID-19* / complications
Child
Connective Tissue Diseases*
Dendritic Cells
Humans
Monocytes
Myocarditis* / diagnosis
SARS-CoV-2
Systemic Inflammatory Response Syndrome

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related

Grants and funding

K08 HL143183/HL/NHLBI NIH HHS/United States