Abstract
Carboxyboranylamino ethanol (Me2N(BH2CO2H)CH2CH2OH, 1) was prepared in 75.0% yield by an amine-exchange reaction. Compound 1 shows lower cytotoxicity and higher anti-tumor efficacy in vitro towards the SCCVII cell line in comparison with 4-borono-L-phenylalanine (BPA) and methyl 2-hydroxyl-5-(1'-ortho-carbonylmethyl-1',2',3'-triazol-4'-yl)-benzonate (2). The bio-enhancement is interpreted using molecular docking calculations.
MeSH terms
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Amino Alcohols / chemistry
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Amino Alcohols / pharmacology*
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Boron Compounds / chemistry
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Boron Compounds / pharmacology*
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Boron Neutron Capture Therapy*
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Carcinoma, Squamous Cell / drug therapy*
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Cell Line, Tumor
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Drug Discovery*
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Mice
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Molecular Docking Simulation
Substances
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Amino Alcohols
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Antineoplastic Agents
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Boron Compounds