Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin

Takumi Yamane; Yasuyuki Kitaura; Ken Iwatsuki; Yoshiharu Shimomura; Yuichi Oishi

doi:10.1093/bbb/zbab160

Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin

Biosci Biotechnol Biochem. 2021 Oct 21;85(11):2292-2294. doi: 10.1093/bbb/zbab160.

Authors

Takumi Yamane¹, Yasuyuki Kitaura², Ken Iwatsuki¹, Yoshiharu Shimomura³, Yuichi Oishi¹

Affiliations

¹ Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.
² Laboratory of Nutritional Biochemistry, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
³ Department of Food and Nutritional Sciences, College of Bioscience and Biotechnology, Chubu University, Aichi, Japan.

PMID: 34529047
DOI: 10.1093/bbb/zbab160

Abstract

We examined the effects of deletion of branched-chain α-keto acid dehydrogenase kinase (BDK), a key enzyme in branched-chain amino acid catabolism, on hyaluronan synthesis in mice. The skin levels of hyaluronan and the gene expression levels of hyaluronan synthase (Has)2, Has3, and peroxisome proliferator-activated receptor-α were significantly lower in the BDK-knockout group than in the wild-type group.

Keywords: branched-chain amino acid; hyaluronan; hyaluronan synthase; skin.

MeSH terms

Amino Acids, Branched-Chain* / metabolism
Animals
Gene Expression Regulation
Glucuronosyltransferase / genetics
Glucuronosyltransferase / metabolism
Hyaluronan Synthases* / genetics
Hyaluronan Synthases* / metabolism
Hyaluronic Acid* / biosynthesis
Hyaluronic Acid* / metabolism
Mice
Mice, Knockout
PPAR alpha* / genetics
PPAR alpha* / metabolism
Skin* / metabolism

Substances

PPAR alpha
Amino Acids, Branched-Chain
Hyaluronic Acid
Hyaluronan Synthases
Glucuronosyltransferase
Has2 protein, mouse