Intra-abdominal desmoid tumor (IADT) and gastrointestinal stromal tumor (GIST) are both mesenchymal tumors mostly found in gastrointestinal tracts and easily misdiagnosed, which would directly damage the survival prognosis and quality of life of patients. With the advent of the era of precision medicine, the understanding of the above two diseases is more in-depth, and the requirements for accurate diagnosis and individualized precision treatment are more stringent. Moreover, there seems to be some internal relationship between IADT and GIST, and the lack of systematic research and discussion makes clinical decision-making and patient management easy to fall into traps and misunderstandings. Therefore, this paper reviews the clinical characteristics, pathogenesis and treatments of the two, and explore their differences and internal relations, so as to provide research and practical reference for promoting more precise and individualized diagnosis and treatment regimens.
腹内型硬纤维瘤病(IADT)和胃肠间质瘤(GIST)均来源于间叶组织并好发于胃肠道,在临床诊疗工作中极易出现误诊,直接导致患者的预后生存和生活质量受到损害。随着精准医学时代的到来,对于上述两种疾病的认识更加深入,而对于准确诊断及个体化精准治疗的要求也愈加严格。同时,IADT和GIST的发病似乎存在某种内在联系,而系统性研究和讨论的匮乏,使得临床决策和病患管理容易进入陷阱和误区。因而,本文将对两者的临床特征、发病机理和治疗手段进行综述,探讨两者的区别和内在联系,以期为推进更加精准化和个体化的临床诊疗方案提供研究和实践参考。.
Keywords: Clinical feature; Desmoid tumor, intra-abdominal; Diagnosis; Gastrointestinal stromal tumor; Treatment.