Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors

Circ Res. 2021 Oct 29;129(10):949-964. doi: 10.1161/CIRCRESAHA.121.318986. Epub 2021 Sep 21.

Authors

Anwarul Ferdous¹, Sarvjeet Singh¹, Yuxuan Luo¹, Md J Abedin¹, Nan Jiang¹, Cameron E Perry¹, Bret M Evers², Thomas G Gillette¹, Michael Kyba^{3

4}, Maria Trojanowska⁵, Joseph A Hill^{1

6}

Affiliations

¹ Departments of Internal Medicine (Cardiology) (A.F., S.S., Y.L., M.J.A., N.J., C.E.P., T.G.G., J.A.H.), University of Texas Southwestern Medical Center, Dallas.
² Pathology (B.M.E.), University of Texas Southwestern Medical Center, Dallas.
³ Department of Pediatrics (M.K.), University of Minnesota, Minneapolis.
⁴ Lillehei Heart Institute (M.K.), University of Minnesota, Minneapolis.
⁵ Section of Rheumatology, School of Medicine, Boston University, MA (M.T.).
⁶ Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas.

Abstract

[Figure: see text].

Keywords: embryonic structures; limb buds; morphogenesis; myoblasts.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation
Cells, Cultured
Endothelial Cells / cytology
Endothelial Cells / metabolism*
Endothelium, Vascular / cytology*
Endothelium, Vascular / embryology
Endothelium, Vascular / metabolism
Mesoderm / cytology
Mesoderm / embryology
Mesoderm / metabolism
Mice
Mice, Inbred C57BL
Morphogenesis*
MyoD Protein / genetics
MyoD Protein / metabolism
Myoblasts / cytology
Myoblasts / metabolism*
Myogenic Regulatory Factor 5 / genetics
Myogenic Regulatory Factor 5 / metabolism
Proto-Oncogene Protein c-fli-1 / genetics
Proto-Oncogene Protein c-fli-1 / metabolism*

Substances

Fli1 protein, mouse
Myf5 protein, mouse
MyoD Protein
MyoD1 myogenic differentiation protein
Myogenic Regulatory Factor 5
Proto-Oncogene Protein c-fli-1

Grants and funding