A case of tuberculosis and black-grain eumycetoma co-infection in a non-endemic country: clinical presentation and therapeutic management

Sonia Vu; Nicolas Belaube; Ana Canestri; Michel Develoux; Alicia Moreno; Eric Fourniols; Minh Patrick Lê; Ludovic Lassel; Gilles Pialoux; Ruxandra Calin

doi:10.1016/j.ijid.2021.09.040

A case of tuberculosis and black-grain eumycetoma co-infection in a non-endemic country: clinical presentation and therapeutic management

Int J Infect Dis. 2021 Nov:112:186-188. doi: 10.1016/j.ijid.2021.09.040. Epub 2021 Sep 20.

Authors

Affiliations

¹ AP-HP, Infectious Diseases Department, Tenon Hospital, Sorbonne Université, Paris, France.
² AP-HP, Mycology Department, Saint-Antoine Hospital, Sorbonne Université, Paris, France.
³ AP-HP, Orthopaedic Surgery Department, Pitié-Salpêtrière Hospital, Sorbonne Université, Paris, France.
⁴ AP-HP, Pharmacology and Toxicology Laboratory, Paris, France; INSERM UMR-S 1144, Université de Paris, Paris, France.
⁵ AP-HP, Infectious Diseases Department, Tenon Hospital, Sorbonne Université, Paris, France. Electronic address: [email protected].

PMID: 34547485
DOI: 10.1016/j.ijid.2021.09.040

Abstract

We report a case of black-grain eumycetoma co-localized with Mycobacterium tuberculosis infection, presenting as a painless leg abscess and associated with vertebral tuberculosis. The rare association of these two pathogens raises several challenges regarding foreseeable drug interactions, side effects, the most appropriate management, and the potential link between these two diseases.

Keywords: Black-grain eumycetoma; Mycetoma; Therapeutic drug monitoring; Tuberculosis.

Publication types

Case Reports

MeSH terms

Antifungal Agents / therapeutic use
Coinfection* / diagnosis
Coinfection* / drug therapy
Humans
Mycetoma* / diagnosis
Mycetoma* / drug therapy
Spine
Tuberculosis* / complications
Tuberculosis* / diagnosis
Tuberculosis* / drug therapy

Substances

Antifungal Agents