Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer's disease

Zeynep Yildiz; Nezaket Eren; Asuman Orcun; Fatma Münevver Gokyigit; Fatma Turgay; Lale Gündogdu Celebi

doi:10.1002/agm2.12173

Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer's disease

Aging Med (Milton). 2021 Aug 22;4(3):201-205. doi: 10.1002/agm2.12173. eCollection 2021 Sep.

Authors

Zeynep Yildiz¹, Nezaket Eren², Asuman Orcun¹, Fatma Münevver Gokyigit³, Fatma Turgay⁴, Lale Gündogdu Celebi⁵

Affiliations

¹ Biochemistry Laboratory Kartal Dr. Lütfi Kırdar City Hospital Istanbul Turkey.
² Medical Biochemistry Yeni Yüzyıl University Faculty of Medicine Istanbul Turkey.
³ Department of Neurology Gaziosmanpaşa Training and Research Hospital Istanbul Turkey.
⁴ Department of Clinical Biochemistry Sisli Etfal Training and Research Hospital Sisli Turkey.
⁵ Department of Neurology Medical Park Hospital Istanbul Turkey.

Abstract

Objective: We aimed to evaluate apelin-13 levels, total oxidant/antioxidant status in Alzheimer's disease (AD) and to investigate the relationship between these parameters.

Methods: Patients newly diagnosed with AD were enrolled in the study. The control group consisted of age- and gender-matched healthy individuals. Serum levels of apelin-13, total antioxidant status (TAS), and total oxidant status (TOS) were measured. Oxidative stress index was calculated (TOS/TAS) for each participant.

Results: We reported that serum apelin-13 and TAS values were significantly lower in the AD group compared with controls, and they found a fair but insignificant relationship between Apelin-13 and TAS values.

Conclusion: According to our results, we suggested that insufficient apelin-13 and TAS levels may contribute to the pathogenesis of AD.

Keywords: Alzheimer’s disease AD); In this study; apelin; oxidative stress; total antioxidant status (TAS); total oxidant status (TOS); we aimed to investigate apelin‐13 levels in AD and their relation with total antioxidant status (TAS) and total oxidant status (TOS)..