mRNA vaccine effectiveness against COVID-19-related hospitalisations and deaths in older adults: a cohort study based on data linkage of national health registries in Portugal, February to August 2021

Euro Surveill. 2021 Sep;26(38):2100833. doi: 10.2807/1560-7917.ES.2021.26.38.2100833.

Abstract

Through deterministic data linkage of health registries, mRNA vaccine effectiveness (VE) against COVID-19-related hospitalisations and deaths was measured in 1,880,351 older adults. VE against hospitalisations was 94% (95% confidence interval (CI): 88-97) and 82% (95% CI: 72-89) for those 65-79 and ≥ 80 years old, with no evidence of waning 98 days after dose two. VE against mortality was 96% (95% CI: 92-98) and 81% (95% CI: 74-87) in these two age groups.

Keywords: COVID-19 related death; SARS-CoV-2; Vaccine Effectiveness; hospitalisation; older adults.

MeSH terms

  • Aged
  • Aged, 80 and over
  • COVID-19 Vaccines
  • COVID-19*
  • Cohort Studies
  • Hospitalization
  • Humans
  • Information Storage and Retrieval
  • Portugal / epidemiology
  • RNA, Messenger
  • Registries
  • SARS-CoV-2
  • Vaccines*

Substances

  • COVID-19 Vaccines
  • RNA, Messenger
  • Vaccines