Cyclosporine A C_1.5 monitoring reflects the area under the curve in children with nephrotic syndrome: a single-center experience

Background: The currently used single-monitoring method for drug-blood-level evaluation in cyclosporine A (CsA) treatment for nephrotic syndrome (NS) was established through hourly measurements based on adult organ transplantation. However, the pharmacokinetics may differ due to different concomitant medications, age, and conditions. This study was conducted to determine the measurement timing that best reflects the CsA area under the curve (AUC) in pediatric NS.

Methods: This retrospective study included children aged 2-14 years who were started on CsA treatment for idiopathic NS during 2013-2020. AUC_0-4 was calculated from 7 points, before and 0.5, 1, 1.5, 2, 3, and 4 h after administration. Mean values at each timing were compared with age-dependent different drug forms. Correlation between AUC_0-4 and measurement timing was analyzed.

Results: There were 13 patients (11 boys) whose median age during testing was 7.3 years, and the total number of measurements was 94. The highest timing of CsA concentrations was found in C₁ 59.6%. The content liquid used at younger ages had a faster absorption time to peak value and lower blood concentration than those of capsules. Among the significant correlations observed, AUC_0-4 and C_1.5 showed the strongest significant correlation coefficient (r = 0.93, P < 0.001).

Conclusion: In pediatric NS, CsA metabolism may be faster than that in previous organ transplantation. Compared with C₂, C_1.5 monitoring may result in better disease control as it can best reflect the AUC_0-4 and peak values associated with side effects, which are indicators of therapeutic efficacy.