[Progress in application of Bletilla striata polysaccharide in novel drug delivery systems and biomaterials]

Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4666-4673. doi: 10.19540/j.cnki.cjcmm.20210528.604.
[Article in Chinese]

Abstract

As the main active ingredient of the orchidaceous herb Bletilla striata, B. striata polysaccharide(BSP) has pharmacological activities such as promoting coagulation, anti-inflammation, anti-oxidation, promoting wound healing, anti-tumor, and immunomodulation, and is biodegradable and non-toxic. Additionally, it has the material properties of suspension thickening, film-forming adhesion, coating and solubilizing, targeting and slow releasing, effect-enhancing and toxicity-reducing, etc., playing the role of unification of medicines and excipients. Therefore, BSP has a wide application prospect in the fields of drug delivery system and trauma repair. This paper reviews the research progress of BSP application in new drug delivery systems and biomaterials based on the related li-terature in recent years, with the aim of providing reference for the further research and application of BSP.

Keywords: Bletilla striata polysaccharide; adhesion; drug delivery; effect-enhancing and toxicity-reducing; targeting; unification of medicines and excipients; wound dressing.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials*
  • Drug Delivery Systems
  • Orchidaceae*
  • Polysaccharides
  • Wound Healing

Substances

  • Biocompatible Materials
  • Polysaccharides