Nuclear detox of unsaturated fat

Philip J Mannino; C Patrick Lusk

doi:10.1016/j.devcel.2021.09.002

Nuclear detox of unsaturated fat

Dev Cell. 2021 Sep 27;56(18):2539-2541. doi: 10.1016/j.devcel.2021.09.002.

Authors

Philip J Mannino¹, C Patrick Lusk²

Affiliations

¹ Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
² Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA. Electronic address: [email protected].

PMID: 34582769
DOI: 10.1016/j.devcel.2021.09.002

Abstract

Fatty acid saturation in phospholipid bilayers alters their fluidity; whether saturation impacts inner nuclear membrane function has never been addressed. In this issue of Developmental Cell, Romanauska and Köhler (2021) show that the inner nuclear membrane detoxifies itself of unsaturated fatty acids by shunting them into cytosolic lipid droplets.

Publication types

Comment

MeSH terms

Fats, Unsaturated*
Fatty Acids
Fatty Acids, Unsaturated
Membrane Fluidity*
Phospholipids

Substances

Fats, Unsaturated
Fatty Acids
Fatty Acids, Unsaturated
Phospholipids