Characterization of the molecular mechanisms underlying azithromycin-induced cardiotoxicity using human-induced pluripotent stem cell-derived cardiomyocytes

Xiaochen Wang; Ziwei Pan; Jue Wang; Hongkun Wang; Hangping Fan; Tingyu Gong; Qiming Sun; Ye Feng; Ping Liang

doi:10.1002/ctm2.549

Characterization of the molecular mechanisms underlying azithromycin-induced cardiotoxicity using human-induced pluripotent stem cell-derived cardiomyocytes

Clin Transl Med. 2021 Sep;11(9):e549. doi: 10.1002/ctm2.549.

Authors

Xiaochen Wang^{1

2}, Ziwei Pan^{1

2}, Jue Wang^{1

2}, Hongkun Wang^{1

2}, Hangping Fan^{1

2}, Tingyu Gong^{1

2}, Qiming Sun³, Ye Feng^{2

4}, Ping Liang^{1

2}

Affiliations

¹ Key Laboratory of combined Multi-organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
² Institute of Translational Medicine, Zhejiang University, Hangzhou, 310029, China.
³ Department of Biochemistry, Department of Cardiology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
⁴ Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.

No abstract available

Keywords: QT interval; autophagy; azithromycin; cardiotoxicity; iPSC-CMs; lysosome.

Publication types

Letter

MeSH terms

Azithromycin / toxicity*
Cardiotoxicity
Cardiotoxins / toxicity*
Cell Survival / drug effects
Cells, Cultured
Humans
Induced Pluripotent Stem Cells / chemistry
Induced Pluripotent Stem Cells / drug effects*
Induced Pluripotent Stem Cells / metabolism
Myocytes, Cardiac / chemistry
Myocytes, Cardiac / drug effects*
Myocytes, Cardiac / metabolism

Substances

Cardiotoxins
Azithromycin

Publication types

MeSH terms

Substances

Grants and funding