Antifungal peptides from the marine gorgonian-associated fungus Aspergillus sp. SCSIO41501

Phytochemistry. 2021 Dec:192:112967. doi: 10.1016/j.phytochem.2021.112967. Epub 2021 Sep 28.

Abstract

Three undescribed cyclic lipopeptides maribasins C-E and four undescribed linear peptides aspergillipeptides H-K together with three known analogous maribasins A-B and marihysin A were isolated from the marine gorgonian-associated fungus Aspergillus sp. SCSIO 41501 (Trichocomaceae). Their structures were determined by spectroscopic analysis, and their absolute configurations were further confirmed by Marfey's methods. Maribasins C-E and maribasins A-B showed significant antifungal activity against five phytopathogenic fungal strains with MIC values of 3.12-50 μg/disc. Structure-bioactivity relationship exhibited that the β-amino fatty acid chain could significantly affect the antifungal activity of this type of cyclic lipopeptides.

Keywords: Antifungal; Aspergillus sp.; Cyclic lipopeptide; Linear peptide; Marine-derived fungus; Trichocomaceae.

MeSH terms

  • Antifungal Agents* / pharmacology
  • Aspergillus*
  • Fungi
  • Molecular Structure
  • Peptides, Cyclic / pharmacology

Substances

  • Antifungal Agents
  • Peptides, Cyclic