Heritable Thoracic Aortic Aneurysms and Dissections

Tingting Huang MD; Bo Yang

doi:10.1016/j.tvir.2021.100747

Heritable Thoracic Aortic Aneurysms and Dissections

Tech Vasc Interv Radiol. 2021 Jun;24(2):100747. doi: 10.1016/j.tvir.2021.100747. Epub 2021 Jul 26.

Authors

Tingting Huang MD¹, Bo Yang²

Affiliations

¹ Department of Cardiac Surgery, North Campus Research Complex, University of Michigan, Ann Arbor, MI; Xiangya School of Medicine, Central South University, Changsha, People's Republic of China.
² Department of Cardiac Surgery, North Campus Research Complex, University of Michigan, Ann Arbor, MI. Electronic address: [email protected].

PMID: 34602273
DOI: 10.1016/j.tvir.2021.100747

Abstract

A large portion of thoracic aortic aneurysms and dissections (TAAD) have a genetic etiology. In recent decades, numerous genes have been identified as associated with heritable thoracic aortic aneurysms and dissections (HTAAD), providing important insights into the underlying molecular mechanisms of both conditions. Today's sequencing technology has allowed us to screen people with high risk of HTAAD, and provide gene‑tailored treatment and management. This review aims to provide an overview of the genetic basis of HTAAD, its underlying molecular mechanism, and practical recommendations for genetic and clinical evaluation as well as patient management.

Keywords: Clinical evaluation; Genetic evaluation; Genetics; Inheritable thoracic aortic aneurysm and dissection; management.

Publication types

Review

MeSH terms

Aortic Aneurysm, Thoracic* / diagnostic imaging
Aortic Aneurysm, Thoracic* / genetics
Aortic Aneurysm, Thoracic* / surgery
Aortic Dissection* / diagnostic imaging
Aortic Dissection* / genetics
Aortic Dissection* / therapy
Dissection
Humans