Phase separating cell fate

Yu Fu; Yuanyue Shan; Mingfeng Zhang; Duanqing Pei

doi:10.1016/j.stem.2021.09.012

Phase separating cell fate

Cell Stem Cell. 2021 Oct 7;28(10):1677-1678. doi: 10.1016/j.stem.2021.09.012.

Authors

Yu Fu¹, Yuanyue Shan¹, Mingfeng Zhang¹, Duanqing Pei²

Affiliations

¹ Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China.
² Laboratory of Cell Fate Control, School of Life Sciences, Westlake University, Hangzhou, China. Electronic address: [email protected].

PMID: 34624226
DOI: 10.1016/j.stem.2021.09.012

Abstract

How master regulators such as Oct4 can shape 3D genome architecture during cell reprogramming remains poorly understood. In this issue of Cell Stem Cell, Wang et al. (2021) demonstrate that Oct4 undergoes phase separation to reconfigure TAD architecture for cell fate control.

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MeSH terms

Cell Differentiation
Cellular Reprogramming*
Genome
Octamer Transcription Factor-3* / genetics

Substances

Octamer Transcription Factor-3