We report the persistent circulation of third-generation cephalosporin resistant Salmonella Typhi in Mumbai, linked to the acquisition and maintenance of a previously characterized IncX3 plasmid carrying the ESBL gene blaSHV-12 and the fluoroquinolone resistance gene qnrB7 in the genetic context of a triple mutant also associated with fluoroquinolone resistance.
Keywords: antimicrobial resistance (AMR); extended-spectrum beta lactamases (ESBL); genomic epidemiology; third-generation cephalosporins; typhoid fever.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.