Circulation of Third-Generation Cephalosporin Resistant Salmonella Typhi in Mumbai, India

Clin Infect Dis. 2022 Jul 6;74(12):2234-2237. doi: 10.1093/cid/ciab897.

Abstract

We report the persistent circulation of third-generation cephalosporin resistant Salmonella Typhi in Mumbai, linked to the acquisition and maintenance of a previously characterized IncX3 plasmid carrying the ESBL gene blaSHV-12 and the fluoroquinolone resistance gene qnrB7 in the genetic context of a triple mutant also associated with fluoroquinolone resistance.

Keywords: antimicrobial resistance (AMR); extended-spectrum beta lactamases (ESBL); genomic epidemiology; third-generation cephalosporins; typhoid fever.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Cephalosporins / pharmacology
  • Drug Resistance, Bacterial*
  • Fluoroquinolones
  • Humans
  • India / epidemiology
  • Microbial Sensitivity Tests
  • Salmonella typhi* / drug effects
  • Salmonella typhi* / genetics
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Fluoroquinolones
  • beta-Lactamases

Supplementary concepts

  • Salmonella enterica subsp. enterica