Abstract
The MK-0787/MK-0791 is a combination of imipenem (a carbapenem antibiotic) and cilastatin sodium (a dehydro peptidase-I inhibitor) in a 1 to 1 ratio, which produces a higher urinary recovery of imipenem than imipenem alone. The MK-0787/MK-0791 was used in 8 female patients with intrapelvic infections. Clinical efficacies were very good in all the patients. There were neither subjective nor objective side effects nor abnormal laboratory findings.
MeSH terms
-
Adult
-
Bacteria / drug effects
-
Bacterial Infections / drug therapy*
-
Cilastatin
-
Cyclopropanes / administration & dosage*
-
Cyclopropanes / pharmacology
-
Cyclopropanes / therapeutic use
-
Dipeptidases / antagonists & inhibitors*
-
Drug Combinations
-
Drug Evaluation
-
Drug Resistance, Microbial
-
Female
-
Genital Diseases, Female / drug therapy*
-
Humans
-
Imipenem
-
Middle Aged
-
Thienamycins / administration & dosage*
-
Thienamycins / pharmacology
-
Thienamycins / therapeutic use
Substances
-
Cyclopropanes
-
Drug Combinations
-
Thienamycins
-
Cilastatin
-
Imipenem
-
Dipeptidases