[Current status of diagnosis and treatment of gastric cancer peritoneal metastasis]

Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Mar 25;24(3):204-207. doi: 10.3760/cma.j.cn.441530-20201116-00611.
[Article in Chinese]

Abstract

Peritoneal metastasis is the most common distant metastasis of gastric cancer. As an end-stage event of gastric cancer, patients with peritoneal metastasis often have lost the chance of radical resection, and even after palliative surgical resection, the long-term outcomes are still not satisfactory. In recent years, with the application and promotion of laparoscopic technology, neoadjuvant intraperitoneal and systemic chemotherapy, hyperthermic intraperitoneal chemotherapy and cytoreductive surgery, through perioperative comprehensive treatment strategies by multidisciplinary team, the quality of life and survival of patients with peritoneal metastasis have been significantly improved. Some patients with gastric cancer peritoneal metastasis diagnosed by laparoscopy even get the opportunity to have radical cytoreductive surgery and hyperthermic intraperitoneal chemotherapy after neoadjuvant intraperitoneal and systemic chemotherapy. Taking into account the progress in the treatment of gastric cancer peritoneal metastasis in recent years, this article intends to combine current clinical evidence and to discuss the key issues in the course of clinical diagnosis and treatment of gastric cancer peritoneal implantation and metastasis, including the imaging diagnosis of peritoneal metastasis, laparoscopic examination, evaluation of peritoneal metastasis and comprehensive treatment plan.

腹膜种植转移是胃癌常见远处转移方式。作为胃癌终末期事件,发生腹膜转移的胃癌患者往往已经失去手术根治机会,即使行外科手术切除,远期预后仍不理想。近年来,随着腹腔镜技术、腹腔化疗、腹腔热灌注化疗等临床诊疗技术的应用与推广,在多学科诊疗模式及围手术期综合治疗策略的支持下,一部分已经发生腹膜转移的胃癌患者获得了根治性手术切除机会,提高了生活质量,延长了生存时间。考虑到近年胃癌腹膜转移治疗领域的进展,本文拟结合目前临床证据,对胃癌腹膜种植转移的临床诊疗过程中的关键问题,包括腹膜转移的影像学诊断、腹腔镜检查、腹膜转移的评估以及综合诊疗方案进行讨论。.

Keywords: Diagnosis; Peritoneal metas-tasis; Stomach neoplasms; Therapy.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Combined Modality Therapy
  • Cytoreduction Surgical Procedures
  • Humans
  • Hyperthermia, Induced*
  • Peritoneal Neoplasms* / drug therapy
  • Peritoneal Neoplasms* / therapy
  • Peritoneum
  • Quality of Life
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / therapy