Goodbye PAM: Phage λ's Red recombination system cripples PAMs and helps dodge CRISPR attacks

Khang Ho; Rasika M Harshey

doi:10.1016/j.chom.2021.09.011

Goodbye PAM: Phage λ's Red recombination system cripples PAMs and helps dodge CRISPR attacks

Cell Host Microbe. 2021 Oct 13;29(10):1469-1471. doi: 10.1016/j.chom.2021.09.011.

Authors

Khang Ho¹, Rasika M Harshey²

Affiliations

¹ Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
² Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: [email protected].

Abstract

Ever wondered how the phage λ Red recombination system resembles the Red Queen? Hossain et al. (2021) provide an answer in this issue of Cell Host & Microbe. They show that Red debilitates PAM sequences by mutagenic repair of CRISPR-targeted DNA breaks in infecting λ, thus shaping the phage-CRISPR arms race.

Publication types

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MeSH terms

Bacteriophage lambda* / genetics
Clustered Regularly Interspaced Short Palindromic Repeats*
Recombination, Genetic

Abstract

Publication types

MeSH terms

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