Phosphine-Catalyzed Synthesis of 3-Allyl-4-pyrones by the Tandem Reaction of Diynones and Allylic Alcohols

J Org Chem. 2021 Nov 5;86(21):14476-14484. doi: 10.1021/acs.joc.1c01340. Epub 2021 Oct 18.

Abstract

A simple and effective tandem reaction of diynones and allylic alcohols was developed to afford functionalized 3-allyl-4-pyrones in moderate to excellent yields. This protocol underwent a Michael addition─Claisen rearrangement─O-cyclization process, which exhibited broad substrate tolerance, high regioselectivity, and atom economy under a metal-free condition. Moreover, functional transformation of the products was also further studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Cyclization
  • Molecular Structure
  • Phosphines
  • Pyrones*

Substances

  • Phosphines
  • Pyrones
  • phosphine