The prognosis of "sandwich" mode of postoperative chemotherapy and radiation in patients with locally advanced cervical cancer

Objective: This study aims to evaluate the survival outcome between different postoperative radiation and chemotherapy modes in locally advanced cervical cancer (LACC).

Methods: This study is a retrospective cohort study. A total of 150 patients with LACC underwent radical hysterectomy combined with postoperative radiation and /or chemotherapy from October 2009 to October 2019. Of those, 101 patients who received "sandwich" adjuvant chemotherapy and radiation (SCR) were enrolled into group A and 49 patients who received simple radiation were enrolled into group B. The primary outcome was the rates of progression-free survival (PFS) and overall survival (OS).

Results: Of 150 patients, 95.3% (143/150) patients complete the study. The rates of deep myometrial invasion (92% and 72.9%, p = 0.007), lymph vascular invasion positive (74.3% and 26.5%, p = 2.59 × 10^-8 ), positive surgical margin (11.9% and 0%, p = 0.012), and lymph-node involvement (40.6% vs. 4.1%, p = 4.0 × 10^-6 ) at baseline were higher in the group A than group B. There was no difference between the follow-up time of group A and group B (45.81 ± 16.83 vs. 45.81 ± 16.84 months, p = 0.665). After the postoperative adjuvant, group A achieved the comparable PFS to group B [p = 0.40; hazard ratio (HR), 1.45; 95% CI, 0.62-3.38]. The cumulative rate of OS in group A was comparable in group B (p = 0.31; HR, 1.53; 95% CI, 0.68-3.45).

Conclusions: Postoperative 'sandwich' chemotherapy and radiation could yield a similar survival rate to radiation alone in LACC women with high-risk factors such as deep interstitial infiltration, lymphatic vascular space infiltration, positive resection margin, and lymph-node metastasis.