Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling

J Mol Cell Biol. 2021 Dec 30;13(10):760-762. doi: 10.1093/jmcb/mjab068.

Authors

Kuan Feng^{1

2}, Yuan-Qin Min^{1

3}, Xiulian Sun^{1

3}, Fei Deng^{1

3}, Peiqing Li², Hualin Wang^{1

3}, Yun-Jia Ning^{1

3}

Affiliations

¹ State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
² Department of Pediatric Emergency, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.
³ Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 / immunology*
COVID-19 / virology
Humans
Interferons / metabolism*
Protein Binding / immunology
Protein Interaction Mapping
SARS-CoV-2 / immunology*
SARS-CoV-2 / metabolism
SARS-CoV-2 / pathogenicity
STAT1 Transcription Factor / metabolism*
Signal Transduction / immunology
Viral Nonstructural Proteins / metabolism*

Substances

STAT1 Transcription Factor
STAT1 protein, human
Viral Nonstructural Proteins
Interferons