Estimation of patient effective doses in PET/CT- 18F-Sodium Fluoride examinations

Meshari Alnaaimi; Abdelmoneim Sulieman; Nissren Tamam; Mohammed Alkhorayef; Musa Alduaij; Talal Mohammedzein; Othman I Alomair; Y Alashban; H Salah; Amr A Abd-Elghany; Hiba Omer; D A Bradley

doi:10.1016/j.apradiso.2021.109965

Estimation of patient effective doses in PET/CT- ¹⁸F-Sodium Fluoride examinations

Appl Radiat Isot. 2021 Dec:178:109965. doi: 10.1016/j.apradiso.2021.109965. Epub 2021 Oct 7.

Authors

Affiliations

¹ Radiation Physics Department, Kuwait Cancer Control Center, Shwiekh, Kuwait. Electronic address: [email protected].
² Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, P.O.Box 422, Alkharj, 11942, Saudi Arabia; College of Medical Radiologic Science, Sudan University of Science and Technology, P.O.Box 1908, Khartoum, 11111, Sudan.
³ Physics Department, College of Sciences, Princess Nourah Bint Abdulrahman University, P.O Box 84428, Riyadh, 11671, Saudi Arabia.
⁴ Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh, 11433, Saudi Arabia; Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK.
⁵ Radiation Physics Department, Kuwait Cancer Control Center, Shwiekh, Kuwait.
⁶ Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh, 11433, Saudi Arabia.
⁷ INAYA Medical Collage, Nuclear Medicine Department, Riyadh, Saudi Arabia.
⁸ Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, P.O.Box 422, Alkharj, 11942, Saudi Arabia; Biophysics Department, Faculty of Science, Cairo University, Egypt.
⁹ Department of Basic Sciences, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University P.O.Box 1982, Dammam, 34212, Saudi Arabia.
¹⁰ Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK; Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia.

PMID: 34688024
DOI: 10.1016/j.apradiso.2021.109965

Abstract

The positron emitters (¹⁸F-Sodium Fluoride (NaF)) and X-rays used in Positron emission tomography (PET) combined with computed tomography (PET/CT) imaging have a high radiation dose, which results in a high patient dose. The present research intends to determine the radiation dose and risks associated with PET/CT- 18F-Sodium fluoride examinations in patients. The 18F-NaF PET/CT was used to investigate the doses of 86 patients. Patient exposure parameters and ImPACT software were used to calculate mean effective doses. The administered activity of 185 MBq (5.0 mCi) per procedure has a mean and range based on the patient's BMI (BMI). The range of patient effective doses per procedure was found to be 4-10 mSv, with a radiation risk of 1 × 10^-5 per procedure. Patient doses are determined by the patient's size, scanner type, imaging protocol, and reconstruction method. For further dose reduction, proper justification and radiation dose optimization is required.

Keywords: (18)F–NaF; Nuclear medicine; PET/CT; Patient dosimetry; Radiology.

MeSH terms

Adult
Aged
Aged, 80 and over
Body Mass Index
Female
Fluorine Radioisotopes / administration & dosage*
Humans
Male
Middle Aged
Positron Emission Tomography Computed Tomography / methods*
Radiation Dosage*
Sodium Fluoride / administration & dosage*
Young Adult

Substances

Fluorine Radioisotopes
Sodium Fluoride
Fluorine-18