Heterologous Ad26.COV2.S Prime and mRNA-Based Boost COVID-19 Vaccination Regimens: The SWITCH Trial Protocol

Roos S G Sablerolles; Abraham Goorhuis; Corine H GeurtsvanKessel; Rory D de Vries; Anke L W Huckriede; Marion P G Koopmans; Melvin Lafeber; Douwe F Postma; Debbie van Baarle; Leo G Visser; Virgil A S H Dalm; Neeltje A Kootstra; Wim J R Rietdijk; P Hugo M van der Kuy

doi:10.3389/fimmu.2021.753319

Heterologous Ad26.COV2.S Prime and mRNA-Based Boost COVID-19 Vaccination Regimens: The SWITCH Trial Protocol

Front Immunol. 2021 Sep 24:12:753319. doi: 10.3389/fimmu.2021.753319. eCollection 2021.

Authors

Roos S G Sablerolles^{1

2}, Abraham Goorhuis^{3

4}, Corine H GeurtsvanKessel⁵, Rory D de Vries⁵, Anke L W Huckriede⁶, Marion P G Koopmans⁵, Melvin Lafeber¹, Douwe F Postma⁷, Debbie van Baarle^{6

8}, Leo G Visser⁹, Virgil A S H Dalm¹⁰, Neeltje A Kootstra¹¹, Wim J R Rietdijk², P Hugo M van der Kuy²

Affiliations

¹ Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands.
² Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, Netherlands.
³ Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centers, Amsterdam, Netherlands.
⁴ Infection & Immunity, Amsterdam Public Health, University of Amsterdam, Amsterdam, Netherlands.
⁵ Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands.
⁶ Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
⁷ Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands.
⁸ Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
⁹ Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
¹⁰ Department of Internal Medicine, Division of Allergy & Clinical Immunology and Department of Immunology, Erasmus University Medical Center, Rotterdam, Netherlands.
¹¹ Department of Medical Microbiology, Amsterdam University Medical Centers, Amsterdam Infection and Immunity Institute, University of Amsterdam, Amsterdam, Netherlands.

No abstract available

Keywords: Ad26.Cov2.S; BNT162.b2; COVID-19; Heterologous vaccine regimen; Homologous vaccination regimen; SARS-CoV-2; mRNA1273; randomized clinical trial.

Publication types

Clinical Trial Protocol

MeSH terms

2019-nCoV Vaccine mRNA-1273
Ad26COVS1
BNT162 Vaccine
COVID-19 Vaccines / administration & dosage*
COVID-19* / immunology
COVID-19* / prevention & control
Humans
Immunization, Secondary

Substances

Ad26COVS1
COVID-19 Vaccines
2019-nCoV Vaccine mRNA-1273
BNT162 Vaccine

Supplementary concepts

COVID-19 vaccine booster shot