MCM3AP-AS1: An Indispensable Cancer-Related LncRNA

Xiao Yu; Qingyuan Zheng; Qiyao Zhang; Shuijun Zhang; Yuting He; Wenzhi Guo

doi:10.3389/fcell.2021.752718

MCM3AP-AS1: An Indispensable Cancer-Related LncRNA

Front Cell Dev Biol. 2021 Oct 7:9:752718. doi: 10.3389/fcell.2021.752718. eCollection 2021.

Authors

Xiao Yu^{1

2

3

4}, Qingyuan Zheng^{1

2

3

4}, Qiyao Zhang^{1

2

3

4}, Shuijun Zhang^{1

2

3

4}, Yuting He^{1

2

3

4}, Wenzhi Guo^{1

2

3

4}

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³ Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, China.
⁴ Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, China.

Abstract

Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed in human cancers. It is significantly associated with many clinical characteristics, such as tumor size, tumor-node-metastasis (TNM) stage, and pathological grade. Additionally, it considerably promotes or suppresses tumor progression by controlling the biological functions of cells. MCM3AP-AS1 is a promising biomarker for cancer diagnosis, prognosis evaluation, and treatment. In this review, we briefly summarized the published studies on the expression, biological function, and regulatory mechanisms of MCM3AP-AS1. We also discussed the clinical applications of MCM3AP-AS1 as a biomarker.

Keywords: MCM3AP-AS1; biological function; biomarker; long non-coding RNA; regulatory mechanism.

Publication types

Review