Surgical-site infections are potential complications of total joint arthroplasties. Many strategies, ranging from preoperative to postoperative, have been developed in an attempt to mitigate this morbidity. Biofilms have been implicated in difficulties of treatment. Therefore, antimicrobials have been increasingly used to combat these problems. In this report, we will summarize different protocols which utilize a new antimicrobial solution. Providing surgeons with an effective prevention option for these infections is crucial for positive outcomes and the continued advancement in the practice of total joint arthroplasty.