Working together: Heterotypic clusters and collective cell migration in melanoma metastasis

William T Frantz; Craig J Ceol

doi:10.1016/j.devcel.2021.10.003

Working together: Heterotypic clusters and collective cell migration in melanoma metastasis

Dev Cell. 2021 Oct 25;56(20):2783-2784. doi: 10.1016/j.devcel.2021.10.003.

Authors

William T Frantz¹, Craig J Ceol²

Affiliations

¹ Program in Molecular Medicine and Department of Cancer Biology, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA 01605, USA.
² Program in Molecular Medicine and Department of Cancer Biology, University of Massachusetts Chan Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: [email protected].

PMID: 34699785
DOI: 10.1016/j.devcel.2021.10.003

Abstract

In this issue of Developmental Cell, Campbell et al. (2021) show that melanoma cells with distinct invasive or proliferative gene signatures can form heterotypic clusters that extravasate collectively and readily seed the growth of metastatic lesions. These findings highlight interactions between heterogenous tumor cells as being critical for metastasis.

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MeSH terms

Cell Count
Cell Movement
Humans
Melanoma*