The translational neuroscience of sleep: A contextual framework

Science. 2021 Oct 29;374(6567):568-573. doi: 10.1126/science.abj8188. Epub 2021 Oct 28.

Abstract

Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists in a social-environmental context. Contextualizing sleep health with respect to its determinants—from individual- to societal-level factors—would enable neuroscientists to more effectively translate sleep health into clinical practice. Key challenges and opportunities pertain to (i) recognizing and exploring sleep’s functional roles, (ii) clarifying causal mechanisms in relation to key outcomes, (iii) developing richer model systems, (iv) linking models to known contextual factors, and (v) leveraging advances in multisensory technology. Meeting these challenges and opportunities would help transcend disciplinary boundaries such that social-environmental considerations related to sleep would become an ever-greater presence in the clinic.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Behavior
  • Cardiovascular Diseases / etiology
  • Cognition
  • Health*
  • Humans
  • Immune System / physiology
  • Mental Health
  • Metabolic Diseases / epidemiology
  • Metabolic Diseases / etiology
  • Neurosciences
  • Sleep / physiology*
  • Sleep Hygiene / physiology*
  • Sleep Wake Disorders / complications
  • Sleep Wake Disorders / epidemiology
  • Sleep Wake Disorders / physiopathology*
  • Sociological Factors*
  • Translational Research, Biomedical