A fatal case of extensive gastrointestinal necrosis due to portal and mesenteric vein thrombosis in the post-acute phase of COVID-19

Tomohiro Hosoda; Hideki Orikasa

doi:10.1016/j.jiac.2021.10.015

A fatal case of extensive gastrointestinal necrosis due to portal and mesenteric vein thrombosis in the post-acute phase of COVID-19

J Infect Chemother. 2022 Jan;28(1):108-111. doi: 10.1016/j.jiac.2021.10.015. Epub 2021 Oct 21.

Authors

Tomohiro Hosoda¹, Hideki Orikasa²

Affiliations

¹ Department of Infectious Disease, Kawasaki Municipal Kawasaki Hospital, Japan. Electronic address: [email protected].
² Department of Diagnostic Pathology, Kawasaki Municipal Kawasaki Hospital, Japan. Electronic address: [email protected].

Abstract

Portal vein thrombosis (PVT) is considered a relatively rare thrombotic complication in coronavirus disease 2019 (COVID-19). Most reported cases of PVT develop within 2 weeks from COVID-19 onset. We report a fatal case of extensive gastrointestinal necrosis due to portal and mesenteric vein thrombosis approximately 6 weeks after the onset of critical COVID-19. Excessive elevation of his plasma D-dimer level had continued for weeks during the hospitalization contrary with improvement of respiratory failure. Thrombotic complication should be cautiously paid attention even in the post-acute phase of COVID-19, especially in patients with persistent elevation of plasma D-dimer level.

Keywords: Coronavirus disease 2019; D-dimer; Gastrointestinal necrosis; Portal vein thrombosis; Post-acute phase; SARS-CoV-2.

Publication types

Case Reports

MeSH terms

COVID-19*
Humans
Mesenteric Veins
Necrosis
Portal Vein / diagnostic imaging
SARS-CoV-2
Thrombosis*