Impaired Humoral but Substantial Cellular Immune Response to Variants of Concern B1.1.7 and B.1.351 in Hemodialysis Patients after Vaccination with BNT162b2

Constantin J Thieme; Arturo Blazquez-Navarro; Lema Safi; Sviatlana Kaliszczyk; Krystallenia Paniskaki; Isabel E Neumann; Kita Schmidt; Mara Stockhausen; Jan Hörstrup; Ocan Cinkilic; Linus Flitsch-Kiefner; Toni L Meister; Corinna Marheinecke; Stephanie Pfaender; Eike Steinmann; Felix S Seibert; Ulrik Stervbo; Timm H Westhoff; Toralf Roch; Nina Babel

doi:10.1681/ASN.2021050672

Impaired Humoral but Substantial Cellular Immune Response to Variants of Concern B1.1.7 and B.1.351 in Hemodialysis Patients after Vaccination with BNT162b2

J Am Soc Nephrol. 2021 Nov;32(11):2725-2727. doi: 10.1681/ASN.2021050672.

Authors

Constantin J Thieme¹, Arturo Blazquez-Navarro^{1

2}, Lema Safi², Sviatlana Kaliszczyk², Krystallenia Paniskaki³, Isabel E Neumann¹, Kita Schmidt¹, Mara Stockhausen², Jan Hörstrup⁴, Ocan Cinkilic⁵, Linus Flitsch-Kiefner⁶, Toni L Meister⁷, Corinna Marheinecke⁷, Stephanie Pfaender⁷, Eike Steinmann⁷, Felix S Seibert², Ulrik Stervbo², Timm H Westhoff², Toralf Roch^{1

2}, Nina Babel^{1

2}

Affiliations

¹ Berlin Center for Advanced Therapies, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
² Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Herne, Germany.
³ Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
⁴ Kuratorium für Dialyse und Nierentransplantat, Berlin, Germany.
⁵ Dialyse Schwerte, Schwerte, Germany.
⁶ Kuratorium für Dialyse und Nierentransplantat, Hagen, Germany.
⁷ Department of Molecular and Medical Virology, Ruhr University, Bochum, Germany.

No abstract available

Keywords: COVID-19; SARS-CoV-2; cellular; chronic hemodialysis; clinical immunology; immunity; infectious diseases; kidney disease; mRNA vaccine; vaccination.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
BNT162 Vaccine
COVID-19 / prevention & control
COVID-19 Vaccines*
Case-Control Studies
Humans
Immunity, Cellular / physiology*
Immunity, Humoral / physiology*
Renal Dialysis*
Renal Insufficiency / immunology*
Renal Insufficiency / therapy
SARS-CoV-2 / immunology*

Substances

Antibodies, Viral
COVID-19 Vaccines
BNT162 Vaccine