Nanomedicine for increasing the oral bioavailability of cancer treatments

Alessandro Parodi; Polina Buzaeva; Daria Nigovora; Alexey Baldin; Dmitry Kostyushev; Vladimir Chulanov; Lyudmila V Savvateeva; Andrey A Zamyatnin Jr

doi:10.1186/s12951-021-01100-2

Nanomedicine for increasing the oral bioavailability of cancer treatments

J Nanobiotechnology. 2021 Oct 30;19(1):354. doi: 10.1186/s12951-021-01100-2.

Authors

Alessandro Parodi^{1

2}, Polina Buzaeva³, Daria Nigovora³, Alexey Baldin⁴, Dmitry Kostyushev^{5

6}, Vladimir Chulanov^{5

6

7}, Lyudmila V Savvateeva³, Andrey A Zamyatnin Jr^{8

9

10

11}

Affiliations

¹ Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia. [email protected].
² Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia. [email protected].
³ Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
⁴ Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia.
⁵ Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia.
⁶ National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994, Moscow, Russia.
⁷ Department of Infectious Diseases, Sechenov University, 119991, Moscow, Russia.
⁸ Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia. [email protected].
⁹ Sirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia. [email protected].
¹⁰ Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia. [email protected].
¹¹ Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7X, UK. [email protected].

Abstract

Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.

Keywords: Biological barriers; Cancer treatment; Oral nanomedicine.

Publication types

Review

MeSH terms

Administration, Oral
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Biological Availability
Drug Delivery Systems
Humans
Nanomedicine*
Neoplasms / drug therapy*
Pharmaceutical Preparations

Substances

Antineoplastic Agents
Pharmaceutical Preparations

Grants and funding

(grant # 21-75-30020)/Russian Science Foundation