Kounis Syndrome Associated With Takotsubo Syndrome in an Adolescent With Peutz-Jeghers Syndrome

Chiara Di Filippo; Mattia Giovannini; Silvia Gentile; Francesca Mori; Giulio Porcedda; Mariangela Manfredi; Giovanni Battista Calabri; Luciano De Simone; Silvia Favilli; Nicholas George Kounis

doi:10.1016/j.jaccas.2021.07.008

Kounis Syndrome Associated With Takotsubo Syndrome in an Adolescent With Peutz-Jeghers Syndrome

JACC Case Rep. 2021 Oct 20;3(14):1602-1606. doi: 10.1016/j.jaccas.2021.07.008.

Affiliations

¹ Cardiology Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.
² Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.
³ Cardiology Unit, Santa Maria Nuova Hospital, Florence, Italy.
⁴ Immunology and Allergy Laboratory, San Giovanni di Dio Hospital, Florence, Italy.
⁵ Department of Cardiology, Patras University School of Medicine, Patras, Greece.

Abstract

We describe the case of a 15-year-old female patient with Peutz-Jeghers syndrome who presented with vomiting and abdominal pain secondary to ileoileal invagination. Initial analgesic treatment was not effective, and subsequent tramadol infusion resulted in clinical manifestations compatible with Kounis and Takotsubo syndromes. However, the patient had an excellent recovery. (Level of Difficulty: Advanced.).

Keywords: ECG, electrocardiogram; EF, ejection fraction; KS, Kounis syndrome; LAD, left anterior descending (coronary artery); LV, left ventricular; NT-proBNP, N-terminal pro–B-type natriuretic peptide; TTS, Takotsubo syndrome; acute heart failure; cardiac magnetic resonance; echocardiography; hs-cTnT, high-sensitivity cardiac troponin; inotropic agents; myocardial ischemia; pulmonary edema; sIgE, specific immunoglobulin E.

Publication types

Case Reports