Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency

Aline Azabdaftari; Holm H Uhlig

doi:10.1126/sciimmunol.abm0293

Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency

Sci Immunol. 2021 Nov 5;6(65):eabm0293. doi: 10.1126/sciimmunol.abm0293. Epub 2021 Nov 5.

Authors

Aline Azabdaftari¹, Holm H Uhlig^{1

2

3}

Affiliations

¹ Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.
² Department of Paediatrics, University of Oxford, Oxford, UK.
³ NIHR Oxford Biomedical Research Centre, Oxford, UK.

PMID: 34739344
DOI: 10.1126/sciimmunol.abm0293

Abstract

New data suggest how epithelial dysfunction and intestinal dysbiosis contribute to inflammatory bowel disease in patients and in models of XIAP deficiency (see the related Research Articles by Strigli et al. and Wahida et al.).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gastrointestinal Microbiome*
Genetic Diseases, X-Linked
Lymphoproliferative Disorders
Paneth Cells*

Supplementary concepts

Lymphoproliferative Syndrome, X-Linked, 2

Grants and funding

DH_/Department of Health/United Kingdom